E-Book

E-Book 2nd Congress

  • Biochemical profiles and expression of some microRNAs in rheumatoid arthritis
  • Sepideh Ghodousifar,1,*
    1. Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran


  • Introduction: While the reason for rheumatoid arthritis is unclear, it is assumed to affect genetic and environmental factors. Considerable investigators have recently thought about the potential that microRNAs are involved in the pathogenesis of RA, and they have lately become more critical in this subject. Considerable studies have revealed the altered expression of many microRNAs in both inflammatory and metabolic disorders.
  • Methods: The central objective of this review is to consider how miRNAs act by controlling cellular and molecular targets in rheumatoid arthritis. Two advanced searches were conducted in databases, one using "micro-RNA" and "rheumatoid arthritis" as keywords and another one with "micro-RNA," "Biochimical," and "metabolic."
  • Results: Because considerable amounts of miRNAs are found in the body fluids, especially in the bloodstream, they supply the unparalleled potential for novel biomarkers: they exhibit specific properties for certain disorders and are readily available and stable molecules. Therefore, examining miRNA patterns in liquid biopsies represents a promising way for the early detection of rheumatoid arthritis and other diseases.
  • Conclusion: This review explains that the unregulating of crucial miRNAs, such as miR-146a-5p and miR-155-5p, could result in RA and metabolic disease. These miRNAs handle critical molecular pathways involved in nociception, inflammation, and autoimmune responses; the NF-κB, TNF-α, interleukins, and TLR4. Finally, microRNAs may play a vital function in RA as an epigenetic connection between RA inflammation and cardiometabolic diseases.
  • Keywords: microRNAs; miR-4270; miR-146b; Rheumatoid Arthritis; Biochemical profiles