E-Book 2nd Congress

  • oxidative stress during Virus infection
  • Saeed Motlaghzadeh,1,* Mehrsa Rashidpour,2 Nafiseh Bahari,3 Fatemeh Noori Pour,4 Najmeh Sheikhi,5 Azarmidokht Aminazad,6
    1. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
    2. Department of genetics, Faculty of basic sciences, Mashhad University, Mashhad, Iran
    3. Department of genetics, Faculty of basic sciences, Mashhad University, Mashhad, Iran
    4. Department of molecular and cellular, Faculty of Basic sciences, Shiraz University, Shiraz, Iran
    5. Department of Virology, Faculty of Medicine, KhoramAbbad University, khorramabad, Iran
    6. Department of genetics, School of medicine, Tehran university of medical sciences, Tehran, Iran


  • Introduction: Some viruses are responsible the proliferation and death of host cells by affecting mitochondria and production of reactive oxygen species (ROS). Dysfunction of mitochondria especially in the pathway of Adenosine 5′-triphosphate (ATP) production leads to the production of free radical oxygen. In addition, the endoplasmic reticulum (ER) can also trigger oxidative stress. Oxidative stress is created by viruses that damage the body through regulating the activity of the immune system, increasing integration rate due to chromosomal instability and etc. This can result in a variety of cancers and problems such as encephalitis and organ dysfunction. A review study was carried out on the effects of oxidative stress on cells damage on 10 viruses, including HPV, EBV, SARS-CoV-2, Influenza(A), Rabies, Zika, Dengue, HSV-1, HIV-1 and Mumps.
  • Methods: Animal and human studies related to brain-damaging viruses and oxidative stress from 1990 to 2022 were extracted and analyzed from reliable scientific databases such as Pubmed and Google Scholar.
  • Results: The results showed that the damage caused by the decrease of antioxidants in the body, especially superoxide dismutase (SOD) and glutathione peroxidase (GPO) are very critical for brain damage. Viruses such as Zika, SARS-CoV-2, HIV-1, influenza-A, EBV, mumps, rabies, dengue, herpes simplex-1 and HPV play a critical role in the imbalance in the antioxidant system due to increasing Oxidants in cell which can lead to oxidative stress and because of that, damage to different cells leads to organ dysfunction such as brain.
  • Conclusion: Considering the various body injuries caused by the oxidative stress which is induced by viruses, we can obtain antioxidants through diet to decrease oxidative stress which is responsible for many damages caused by viruses and new approaches must go under investigation to pave the path of the exact mechanism of oxidative stress in virus pathogenesis.
  • Keywords: Cancer, oxidative stress, HPV