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  • Calprotectin as a serodiagnostic marker for bacterial sepsis
  • Faranak Rezaei,1,* Samin Ahmadi,2 Amirreza Mousivand,3 Zahra Bakhshiani,4 Saloomeh Fouladi,5 Faeze Ahmadi,6
    1. Department of Microbiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
    2. Student Research Committee, Faculty of paramedical sciences, Lorestan University of Medical Sciences, Khorramabad, Iran .
    3. Student Research Committee, Faculty of paramedical sciences, Lorestan University of Medical Sciences, Khorramabad, Iran .
    4. School of Medicine, Islamic Azad University, Najafabad Branch, Isfahan, Iran
    5. School of Medicine, Islamic Azad University, Najafabad Branch, Isfahan, Iran
    6. Student Research Committee, Faculty of paramedical sciences, Lorestan University of Medical Sciences, Khorramabad, Iran .


  • Introduction: This study aimed to assess the serum levels of calprotectin and a more widely used sepsis biomarker in patients with bacterial sepsis (BS).
  • Methods: Subjects were classified into the BS group with patients who met the sepsis criteria at the beginning of the study and the control group. We investigated concentrations of the biomarkers in 300 blood samples collected at admission from all patients hospitalized in the Fatemeh Al-Zahra Hospital, Najafabad, Isfahan in April 2019 and April 2020.
  • Results: The microbial etiology in the BS group was confirmed in 35 patients (100%). The most frequently cultivated pathogens were Escherichia coli (n=11). The serum concentrations of calprotectin and CRP were significantly higher in patients with BS (n= 35) than the healthy controls (n= 20).
  • Conclusion: Our results suggest that the serum level of calprotectin could have substantial added value in the management of BS and is a reliable biomarker of BS.
  • Keywords: Bacterial sepsis, Serum calprotectin, C-reactive protein