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  • The study of hepatitis B infection in a patient admitted to Shariati Hospital in Tehran
  • Mohammad Reza Mohammadi,1,* Mohammad Ali Zonobian,2
    1. Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran


  • Introduction: Hepatitis B virus infection causes liver diseases such as cirrhosis and hepatocellular carcinoma. Approximately 30% of the world's population shows serologic evidence of current or past infection. Hepatitis B virus causes liver damage by an immune reaction against virus-infected hepatocytes and is not directly cytopathic, although immunosuppression appears to increase replication and lead to direct cytotoxicity. The interplay between the host's immune response and the ability of the virus to replicate is a major determinant of the likelihood of liver damage, its severity, and the progression of cirrhosis. In this research, the level of liver enzymes, molecular tests, and positive or negative HBe Ag in patients with chronic hepatitis B and liver fibroscan were investigated.
  • Methods: In this study, the patient who had been referred to Shariati Hospital in 2018 was examined for HBS Ag and Anti HCV and liver enzymes. After sampling and isolating the serum from the blood of a patient infected with hepatitis B using a special kit for extracting the viral genome from the individual's serum, the amount of viral DNA was isolated and diagnosed using the Taqman-STD curve method. Real-Time PCR was performed. The information was collected from the results of reading the patients' files. Then, using the results of pathological tests and availability of liver fibroscan, hepatitis B infection in the patient was analyzed.
  • Results: In the patient HBS Ag was positive, Anti HCV was negative. Enzymes of patients were identified as AST: 381 U/L, ALT: 224 U/L, and ALP: 624 U/L. The first session of TACE was performed by DSA and right lobe HCC was diagnosed. Patients' enzymes have been elevated since hospitalization and right lobe HCC has been diagnosed, which is a good indicator of the severity of body involvement. After accurate pathologic diagnosis and fibroscan, antiviral therapy should be started immediately before severe damage increases.
  • Conclusion: The patient was treated after an accurate pathological diagnosis and liver fibroscan, and the patient died due to cirrhosis of the liver.
  • Keywords: HCC, HBV, Hepatitis, enzymes