E-Book 2nd Congress

  • The Effect of Oxidative Stress and Lipids on Breast Cancer
  • Galal Ghorbani,1,* Elyas moghadas khorasani,2 Mina Soleimani,3 Mohammad Sina khanbabazadeh,4
    1. Department of Laboratory Sciences, Faculty of Paramedical, Mashhad Branch, Islamic Azad University, Mashhad, Iran
    2. Department of Laboratory Sciences, Faculty of Paramedical, Shahrud Branch, Islamic Azad University, Shahrud, Iran
    3. Department of Laboratory Sciences, Faculty of Paramedical, Mashhad Branch, Islamic Azad University, Mashhad, Iran
    4. Department of Laboratory Sciences, Faculty of Paramedical, Mashhad Branch, Islamic Azad University, Mashhad, Iran


  • Introduction: Breast cancer is the most common type of cancer in women and is the main cause of death among women's cancers. The improper balance between the production of reactive oxygen metabolites (ROM) as oxidative stress and antioxidant defense system, changes in cholesterol metabolism, lipoproteins, and antioxidant vitamins are associated with breast cancer risk.
  • Methods: relevant articles and updated information were extracted from the reliable scientific databases such as PubMed and Google Scholar search engines.
  • Results: The role of high-density lipoproteins (HDL) is very prominent. In fact, in addition to the role of reverse cholesterol transport (RCT), HDL has antioxidant and anti-inflammatory properties, modulating intracellular cholesterol homeostasis, signal transduction, and proliferation. This means that low levels of HDL cholesterol (HDL-C) have been observed in breast cancer patients, which indicates the role of HDL-C in this cancer. In recent studies, higher levels of lipid peroxidation markers have been observed in the plasma of patients and indicate the inefficiency of HDL in breast cancer patients. Also, reactive oxygen species (ROS) are produced by enzymatic and non-enzymatic systems in eukaryotic cells and play an important role in cellular physiology and pathophysiology. Although physiological concentrations are crucial to ensure cell survival, excessive production of ROS is harmful to cells and is considered a key factor in the development of several diseases such as neurodegenerative diseases, cardiovascular disorders, and cancer. Cancer cells are usually exposed to higher levels of ROS, which further induce a malignant phenotype through stimulation for sustained proliferation, death evasion, angiogenesis, invasiveness, and metastasis.
  • Conclusion: The role of ROS in the cause and progression of breast cancer is gradually being clarified. However, less attention has been paid to the development of targeted strategies of the redox system for the treatment of breast cancer.
  • Keywords: Breast cancer / Oxidative stress / Reactive oxygen species / Cholesterol / High-density lipoprotein