E-Book

E-Book 2nd Congress

  • Dose-dependent histopathological effects of hexaflumuron on the reproductive system of male albino rat
  • Sina Delshad,1 Seyed Mohammad Hosseini,2,*
    1. Department of pathology, Islamic Azad University, Babol branch, Babol, Iran
    2. Department of pathology, Islamic Azad University, Babol branch, Babol, Iran


  • Introduction: Hexaflumuron (HFM) is an insect growth regulator which is widely used in agriculture. Despite its beneficial effects, it is a hazardous substance for human and animal health and has potential risks and harm for non-target organisms. Due to the lack of histopathological assessments of this insecticide on the reproductive system, the present study aims to investigate possible dose-dependent histopathological effects of hexaflumuron on the reproductive system of adult male albino rats.
  • Methods: 16 male rats were divided into five groups of 4 each and received daily treatment by gavage for 28 days as follows: Group (1) control, Group (2) 10% of LD50, (3) 15% of LD50, (4) 20% of LD50 of HFM.
  • Results: Our results reveal moderate to severe histopathological alternations such as a decrease in spermatozoa count, edema, vacuolar degeneration, vascular congestion and hyperemia in the testes, epididymis and prostate gland. These effects have been made mainly by middle and high doses.
  • Conclusion: It can be concluded that exposure to middle and high doses of hexaflumuron led to histopathological alternation in the male reproductive system and also raise concerns about this insecticide that possesses a potential hazard to human health and breeding animals.
  • Keywords: Hexaflumuron, Male reproductive system, Histopathology