E-Book

E-Book 2nd Congress

  • The Role of Microbiome in Pancreatic Cancer
  • Hamed Ebrahimzadeh Leylabadlo,1 Sevda Zoghi,2,*
    1. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    2. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


  • Introduction: Pancreatic cancer (PC) is one of the most lethal malignancies among diseases that is not directly caused by microbial agents. However, considering the diverse biological functions of the microbiome in known disorders, in this review, we aim to investigate the relationship between microbiome and pancreatic carcinogenesis.
  • Methods: Results of clinical trials were searched in the Google Scholar and PubMed databases between 2012 and 2022. In selected articles, novel genetic techniques have demonstrated that each of the healthy and cancerous tissues of the pancreas have distinct and unique microbial profiles.
  • Results: Most studies about microbial causes associated with PC in humans and laboratory animals have confirmed changes in the abundance and diversity of pancreatic, oral and gut microbiota (dysbiosis) compared to the healthy situation. The involvement of some infections in increasing the occurrence risk of PC, and eliminating drug resistance in cancer therapy are other microbial issues. Accordingly, the mechanisms of microbial migration pathways in the gastrointestinal system and blood circulation are currently options under study.
  • Conclusion: Dysbiosis can be closely related to the risk of progression and development of PC. The evidence of the last few years claims that the microbiome associated with PC has a potential role in the tracking, regulation of the host's immune responses during oncogenesis, and the emergence of new effective therapeutic paradigms.
  • Keywords: Pancreatic cancer, Microbiome, Dysbiosis, Gut microbiota, Oral microbiota