E-Book

E-Book 2nd Congress

  • Investigation of Hematological and Coagulation Indices in Patients with Pulmonary Thromboembolism
  • Sina Sohrabian,1,* Fatemeh Badeleh,2 Mohammad Hossein Ahmadi,3
    1. Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
    2. Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran
    3. Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran


  • Introduction: Objective: Pulmonary thromboembolism (PTE) is the most common type of pulmonary embolism, which is mostly caused by venous thromboembolism (DVT), and it has increased significantly in recent years. DVT and PTE both have similar causes of disease. Inflammation is one of the causes of PTE and PTE itself leads to inflammation. The purpose of this review was to evaluate hematological and coagulation inflammatory indices in patients with pulmonary thromboembolism and compare them in two control and patient groups and the prognostic value of these indices.
  • Methods: Methods: Electronic databases including Scopus, PubMed and Google Scholar were searched and related articles were studied. Keywords such as Pulmonary Thromboembolism, Neutrophil to Lymphocyte Ratio, Plasma D-Dimer, and Laboratory Diagnosis were searched and related articles between 2010 and 2022 were studied.
  • Results: Results: Studies have shown that the neutrophil-to-lymphocyte ratio (NLR) is increased in PTE, an important indicator that can determine the state of inflammation and immune system function. In other words, in this disease, the neutrophil count increases and the lymphocyte count decreases. The importance of D-dimer in thrombotic diseases is widely known which is associated with PTE and according to the studies, its level increases. The sensitivity of NLR in the diagnosis of PTE was significantly higher than D-Dimer amount. This feature shows that the combined determination of NLR and D-Dimer has great importance for laboratory diagnosis of PTE. Other hematological inflammatory indices such as lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP), albumin and white blood cell count (WBC), neutrophil (Neu) and monocyte (Mo) were all significantly higher in PTE patients; while the amount of lymphocyte (Lym) was lower compared to the control group. No change in PLT count is another hematological finding of people with PTE. Also, no significant change was observed in markers such as fibrinogen, D-dimer, and CRP in patients with corona and involved with PTE.
  • Conclusion: Conclusion: Although hematological and coagulation indices are critical and significantly altered in diagnosing inflammatory diseases such as PTE, only a few studies have aimed at these issues. Therefore, a greater understanding of the experiences associated with the diagnosis of this inflammatory disease is still needed.
  • Keywords: Keywords: Pulmonary Thromboembolism, D-dimer, platelets, C-reactive protein, neutrophil/lymphocyt