E-Book

E-Book 2nd Congress

  • The miRNA of polyomaviruses
  • Piruz Shadbash,1,* Seyed Reza Mohebbi,2 Seyed Masoud Hosseini,3 Shahnaz Mohamadi,4
    1. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    2. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    3. Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
    4. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


  • Introduction: Polyomaviruses are non-enveloped family of DNA viruses that can infect a number of species, including humans, primates, birds, rodents, bats, horses, cattle, raccoons, and sea lions. They often cause infection with no symptoms and a latent period, but can be reactivated under certain conditions causing severe illness.
  • Methods: MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in a number of cellular processes by binding to and inhibiting the translation of specific mRNA transcripts. In this paper, we summarize current knowledge about microRNAs involved in polyomavirus infection.
  • Results: We review in detail the different viral miRNAs that have been detected and their roles in controlling the expression of host and viral proteins.
  • Conclusion: We also provide an overview of current knowledge on how host miRNAs may function in controlling polyomavirus replication, immune evasion, and pathogenesis.
  • Keywords: Polyomaviruses, MicroRNAs, viral proteins, immune evasion, pathogenesis