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  • Antimicrobial effect of metabolites of fungi isolated from animal feed on Gram-positive bacteria Staphylococcus aureus
  • Mahdi Dadashi Firouzjaei,1,* Issa Gholampour Azizi,,2 Hedyeh Taghizadeh,3
    1. Islamic Azad University Babol Branch, Babol, Iran
    2. Islamic Azad University Babol Branch, Babol, Iran
    3. Islamic Azad University Babol Branch, Babol, Iran


  • Introduction: Secondary metabolites, also called specialised metabolites, toxins, secondary products, or natural products, are organic compounds produced by any lifeform, e.g. bacteria, fungi or plants, which are not directly involved in the normal growth, development, or reproduction of the organism. These compounds, isolated and have been used in modern medicine because of its antimicrobial effects.
  • Methods: In this study secondary metabolites of Aspergillus flavus, Aspergillus fumigatus and penicillium spp. isolated from moldy Livestock ration and its antimicrobial properties against of Staphylococcus aureus was investigated.
  • Results: Results of this study showed that the MIC was 416.66 ± 144.33, 333.33 ± 144.33 and 500 ± 0.00 (ml) respectively for Aspergillus flavus, Aspergillus fumigatus and penicillium spp. secondary metabolites isolated. The MBC was 500 ± 0.00, 416.66 ± 144.33 (ml) respectively for Aspergillus flavus and Aspergillus fumigatus; penicillium spp. had no any bactericidal effect on Staphylococcus aureus. Disk diffusion test shows no inhibitory zone in 100, 120 and 150 µl for secondary metabolites. Also There was no any inhibitory zone around secondary metabolites in well diffusion in 170, 200 and 220 µl.
  • Conclusion: Based on the results; secondary metabolites of Aspergillus flavus, Aspergillus fumigatus and penicillium spp. especially Aspergillus flavus and Aspergillus fumigatus have the antibacterial effects on Staphylococcus aureus.
  • Keywords: Secondary metabolites, Aspergillus flavus, Aspergillus fumigatus, penicillium spp.