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  • The impression of ABO blood group on complications caused by covid-19 infection
  • Mobina Nakhaei Shamahmood,1,* Motahare Sadeghi,2 Younes Sadeghi_bojd,3
    1. Student research committee, school of Allied medical science, zahedan university of medical science, zahedan, Iran
    2. Student research committee, school of Allied medical science, zahedan university of medical science, zahedan, Iran
    3. Department of laboratory sciences, school of Allied medical science, zahedan university of medical science, zahedan, Iran


  • Introduction: The 2019 coronavirus disease (COVID-19) has become a global pandemic. According to the World Health Organization (WHO), about 200 million cases of Covid-19 infection have been reported. Recently, several studies have investigated the association between ABO blood groups and the complications of COVID-19 infection. Therefore, the aim of this systematic review was to evaluate the available evidence regarding the susceptibility of ABO blood group to COVID-19 infection.
  • Methods: Studies of The relationship between ABO's blood group and Covid-19 infection were searched in PubMed, Google Scholar, Scopus, and EMBASE until October 2022. also A search was carried out in Medline and in MedRxive and BioRxive.
  • Results: This systematic review demonstrates the ABO blood group’s vulnerability to COVID-19 infection was significant. blood groups A and B may be risk factors for COVID-19 infection, whereas the blood group O appears to be protective. we also found higher risk of infection in A group compared to non-A, but not with each group independently and a lower risk of infection in O group compared to non-O groups and to each individual group. higher risk of infection in patients without anti-A or anti-B antibodies observed. O group showed a lower risk of infection compared to non-O groups but also with A, B, and AB. Group A, however, only showed a higher risk when comparing with non-A. The reason for the lower sensitivity of people with blood type O to be infected by viruses can be the natural anti-A and anti-B antibodies produced in people with blood type O, which potentially block the adhesion of the virus to cells.
  • Conclusion: We found that the COVID-19 infection rate in persons with blood group A > O > B > AB. Accordingly, this evidence-based systematic review study further indicates blood group A individuals’ vulnerability to COVID-19 infection. Blood type AB is linked to a lower risk of COVID-19 infection.
  • Keywords: Blood Group, COVID-19 infection, infection, Vulnerability.